Category: COX

100,000 cells of metastatic (BB3RC31) PDX were re-implanted subcutaneously in NSG mice with 90-day slow-release estrogen pellets. predicts for an unhealthy response/prognosis in 2 ER+ individual cohorts. Targeting of NOTCH4 reverses the upsurge in BCSC and Notch activity induced by anti-estrogens. Significantly, in PDX tumors with obtained tamoxifen level of resistance, NOTCH4 inhibition decreased BCSC […]