Category: Sirtuin

[PMC free content] [PubMed] [Google Scholar]Luk KC, Kehm V, Carroll J, Zhang B, OBrien P, Trojanowski JQ, Lee VM. pathology, ameliorates substantia nigra dopaminergic neuron reduction, and improves electric motor impairments. We conclude that -syn antibodies could exert healing results in PD/DLB by preventing entrance of pathological -syn and/or its propagation in neurons. Launch Misfolded […]
[PMC free article] [PubMed] [Google Scholar] 28. a novel post-translational modification of 53BP1 by ADP-ribosylation that is targeted by a PAR-binding E3 ubiquitin ligase, RNF146, leading to 53BP1 polyubiquitination and degradation. In response to DNA damage, ADP-ribosylated 53BP1 increased significantly, resulting in its ubiquitination and degradation. These data suggest that NUDT16 plays a major role […]